When the body of a dead scientist, infected with a stolen chemical, is cremated by the US military, a virus is unintentionally released into the atmosphere of a grimy urban wasteland.

An Eastside gang uses the Amityville property to grow marijuana when they are attacked by a rival gang and their drugs stolen. Soon, it's unleashed on the Westside streets of Compton, where anyone who smokes it suffers one KILLER buzz.